Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.
نویسندگان
چکیده
By consensus, the acyl-CoA synthetase (ACS) community, with the advice of the human and mouse genome nomenclature committees, has revised the nomenclature for the mammalian long-chain acyl-CoA synthetases. ACS is the family root name, and the human and mouse genes for the long-chain ACSs are termed ACSL1,3-6 and Acsl1,3-6, respectively. Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made.
منابع مشابه
A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases.
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched-chain), bile acid-CoAs, CoA esters of prostaglandins, etc., to the corresponding free acid and CoA. However, there is significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee...
متن کاملEnzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase.
Recently we found that firefly luciferase is a bifunctional enzyme, catalyzing not only the luminescence reaction but also long-chain fatty acyl-CoA synthesis. Further, the gene product of CG6178 (CG6178), an ortholog of firefly luciferase in Drosophila melanogaster, was found to be a long-chain fatty acyl-CoA synthetase and dose not function as a luciferase. We investigated the substrate speci...
متن کاملHuman very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein.
Several human genes with a high degree of homology to rat very long-chain acyl-CoA synthetase (rVLCS) and mouse fatty acid transport protein (mFATP) were identified. Full-length cDNA clones were obtained for three genes, and predicted amino acid sequences were generated. Initial characterization indicated that one gene was most likely hVLCS, the human ortholog of rVLCS. The other two (hVLCS-H1 ...
متن کاملThe effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart
Objective(s): This study intended to investigate the effects of Ginsenoside-Rbl (Gs-Rbl) on fatty acid β-oxidation (FAO) in rat failing heart and to identify potential mechanisms of Gs-Rbl improving heart failure (HF) by FAO pathway dependent on AMP-activated protein kinase (AMPK). Materials and Methods: Rats with chronic HF, induced by adriamycin (Adr), were randomly grouped into 7 groups. Gs-...
متن کاملAssignment of the acyl-CoA synthetase long-chain family member 4 (ACSL4) gene to porcine chromosome X.
Source/description: Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an essential enzyme in fatty acid metabolism. It converts free long-chain fatty acids into fatty acylCoA esters, which are key intermediates in the synthesis of complex lipids. ACSL4 catalyses the formation of these fatty acyl-CoAs by a two-step process that starts with the addition of an AMP at the carboxyl group of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of lipid research
دوره 45 10 شماره
صفحات -
تاریخ انتشار 2004